MK International Medical - Japanese high-class cell therapy services
MK International Medical - Japanese high-class cell therapy services
What are mesenchymal stem cells(MSCs)?
The most advance anti-aging treatment in the world.
MSCs are characterized by their capability of self-renewal and multipotency to turn into various cell types that constitute bone, cartilage, liver, nerve, heart muscle, etc.
Moreover, MSCs migrate to a site of tissue damage, and secrete cytokines and exosomes, which contain microRNAs. Those secreted factors recruit and activate various types of cells so that they can effectively repair the damaged tissue. Thus, MSCs play a pivotal role in tissue repair and regeneration.
MSC therapy for liver dysfunction
Liver dysfunction from fatty liver, hepatitis or liver cirrhosis causes prolonged inflammation that may result in the development of liver cancer.
MSCs have a potential to differentiate into hepatocytes. In addition, MSCs secrete biologically active substances that can suppress inflammation, alleviate fibrosis, and promote hepatic regeneration. These characteristics make MSCs an attractive therapeutic tool to improve liver dysfunction and to reduce the risk of liver cancer development.
MSC therapy for joint injuries
Joint injuries (e.g., osteoarthritis of the knee) can lead to the abrasion of joint cartilage and severe joint pain. Joint injuries can also be treated using MSCs. MSCs have a potential to differentiate into chondrocytes and osteocytes. In addition, MSCs secrete biologically active substances that can suppress joint inflammation, reduce pain, and improve joint mobility.
Prospect of MSC therapy
Successful application of MSC therapy to liver dysfunction and joint injuries has been reported on human patients.
On the other hand, the usefulness of MSC therapy for some other diseases has been demonstrated in animal models thus far. Such diseases include stroke, myocardial infarction, chronic obstructive pulmonary disease, interstitial pneumonia, inflammatory bowel disease, acute kidney injury, multiple sclerosis, menopausal disorders, chronic skin wounds, androgenetic alopecia. MSC therapy is expected to show efficacy against those diseases in the future.
The Procedure of Adipose MSC Therapy
Preoperative Examination
After the consultation with the doctor,
we will to general blood test and ultrasound to check the condition of your body.
※Cancer patients cannot receive adipose stem cell therapy
Adipose Collecting
We will need you to sign the agreement, then we will start the adipose collecting.
After local anesthesia, an incision of approximately 1 to 3mm will be cut in the right lower abdomen and approximately 10-20g of fat will be collected.
We will also withdraw 60mL of plasma as nutrition for stem cell culturing.
After the collecting, we will deliver the sample to specific cell processing facility for culturing.
Cell Culturing
The adipose stem cells will be cultured in a specific cell processing facility certified by the Ministry of Health, Labor and Welfare.
Infusion and joint injection can be performed five weeks after the initial culture.
In order to let all customers to receive the safest regenerative medicine, all cells cultured and prepared in this facility will undergo thorough quality management and safety testing after completion of culture.
※You can choose to stay in Japan or return to your country during culturing period.
Stem Cell Infusion・Injection
Five weeks after the start of the cell culture, the initial stem cell intravenous (IV) transfusion and arthroplasty can be performed.
The number of cells in the IV infusion is about 100 million and the number of cells for the joints is about 30 million.
The infusion takes about 40 minutes to an hour, the joint injection takes only 10 minutes.
The collected adipose tissue can be used for about 11 treatments. If you would like to do the treatment again, you can use the frozen stem cells. Please contact us at least two weeks before the next treatment date.
